What factors can influence the effectiveness of HBV vaccination?

The effectiveness of HBV (Hepatitis B Virus) vaccination is significantly influenced by age and immune status. This is because the immune system’s ability to respond to vaccines varies with age; for instance, infants and elderly individuals may have a weaker immune response compared to healthy adults. Specifically, younger individuals often have more robust immune systems that can generate a stronger and more lasting response to the vaccine. Additionally, a person’s immune status, which can be affected by various factors such as underlying health conditions, immunosuppressive therapies, or other immunological factors, plays a crucial role in how well they can respond to vaccination. Individuals with compromised immune systems may not develop adequate immunity even after receiving the vaccine, making this factor critical in determining the vaccine's overall effectiveness.