Which of the following symptoms may indicate a serious progression of HIV/AIDS?

Profound and unexplained fatigue is a significant symptom that may indicate a serious progression of HIV/AIDS. This fatigue can be a result of the body’s struggle to fight off infections due to a weakened immune system, which is a hallmark of the disease as it progresses. As HIV/AIDS attacks and destroys immune cells, the body loses its ability to effectively respond to illnesses, leading to increased fatigue even without physical exertion.

Identifying this symptom is crucial, as it can signal the need for further medical evaluation and intervention. In contrast, weight gain might suggest general health improvements or lifestyle changes, an enhanced immune response indicates stronger immunity which is generally a positive sign, and regular exercise typically contributes to better overall health rather than indicating disease progression. Therefore, recognizing unexplained fatigue as a symptom can be vital for timely medical attention and management of the condition.